The Science


When you subscribe to Helix MWR, the goal of our hormone protocol is to use peptides to replenish your hormone-producing organs, use bio-identical hormones to balance your hormone pathways, concluding with the goal to release an optimized amount of bioavailable hormones for your body to use. The organs we seek to stimulate and replenish with peptides are your hypothalamus, pituitary, thyroid and adrenal glands. The individual hormones we seek to balance and optimize are: testosterone, cortisol, thyroid T3, HGH (human growth hormone), progesterone, and estrogen.

Hormone-Organ Stimulation:
Helix MWR uses peptides to stimulate and replenish the hypothalamus, pituitary, thyroid and adrenal glands – particularly hCG for men and GHRH/GHRP combos for women. Dr Albert Simeons first proposed that hCG stimulates and replenishes the hypothalamus, however an increasing amount of research is showing that hCG may also do the same to the pituitary, thyroid and adrenal glands. Similarly, GHRH/GHRP peptides were designed to specifically help the hypothalamus and pituitary, however, some research suggests a positive stimulation on adrenals and thyroid, as well.

Ultimately, the goal is to heal, replenish and stimulate the hypothalamus, pituitary, adrenals and thyroid, so all four organs are working optimally, supplying the body with strong amounts of hormones.

Hormone Pathway:
A major part of the Helix MWR protocol is to make sure the hormone pathways are not overtaxed. One deficient hormone in the pathway can cause the hormone-producing organs (hypothalamus, pituitary, adrenals, thyroid) to overwork itself to heal that deficient hormone, thereby fatiguing itself, crashing as an organ, and crashing the entire pathway. This is often the experience patients may feel who suffer from low testosterone, adrenal fatigue or thyroid issues.

Testosterone tends to be a malnourished hormone as people age – this is often because, according to our in-house research, the propensity for testosterone to convert into estrogen rises with age. For many patients, particularly men, it motivates an estrogen-blocker to be introduced into the pathway. The introduction of this is not to bring estrogen to zero (estrogen is beneficial for both genders) but to control estrogen and preserve optimized testosterone. As you can see in the chart above, estrogen is the last hormone to be produced in the adrenal-pathway, and it may get over-produced for this reason.

Helix MWR uses testosterone, pregnenolone, thyroid T4 and T3, hydrocortisone (cortisol-related) and estrogen-blockers to relieve the hormone pathway. By monitoring the main hormones in the pathway, Helix MWR prescribes whatever hormones are most deficient. If the pathway can be relieved with additional hormones, while the hormone-producing organs are being replenished and stimulated, then we are allowing the hormone-producing organs to spend more energy on intelligently communicating between each other, so that the hormones in the pathway are naturally and intelligently balanced, based on what a person’s body needs.

Bioavailable Hormones:
If the hormone pathway is replenished with needed hormones, while the hormone-producing organs are healed and stimulated, then we hope that the hormone pathway is engulfed with enough hormones so that the body doesn’t ‘store’ them, but rather, releases them so that they are bioavailable for your use. We believe many bodies, particularly as aging occurs, store hormones, rather than make them available for use, due to the body’s fear of aging and need to maintain internal balance. Robust and balanced amounts of hormones in the pathway though, we believe, will cause the body to make more of them bioavailable for use, while still being able to store enough for internal balance, assisting longevity, healing, and happiness.

Our goal is to balance the pathway and to help patients produce optimized amounts of hormones. By subscribing to Helix MWR, we will use peptides and individual hormones to replenish your hormone-producing organs, balance your hormone pathways, and elicit optimized amounts of bioavailable hormones, specifically: testosterone, cortisol, thyroid T3, progesterone, HGH and estrogen.

Protocols and Medications:
Most men with Helix MWR will receive: testosterone, estrogen blockers, pregnenolone and hCG. Most women with Helix MWR will receive human-growth-hormone-inducing peptides along with pregnenolone. Both men and women will also receive thyroid and adrenal medication, if levels show malnourished numbers.

Research Notes:
Helix MWR is proud to be a research company. Our approach to care is based on medical science, research and theory.




The footnotes that motivated our theories are as follows:
Steroidogenic Pathways Chart – by Genova Diagnostics, 2017.

HCG as a Thyroid Stimulator:
The Role of Human Chorionic Gonadotropin as a Thyroid Stimulator in Normal Pregnancy, by Jerome M. Hershman, The Journal of Clinical Endocrinology & Metabolism, Volume 93, Issue 9, 1 September 2008.

The role of hCG in regulation of the thyroid gland in normal and abnormal pregnancy, by Kennedy RL, Darne J. Obstet Gynecol. 1991 Aug;78(2):298-307.

HCG/LH as an Adrenal Gland Stimulator:
(note: proposed that HCG mimics LH – luteinizing hormone):
The adrenal gland may be a target of LH action in postmenopausal women, by Alevizaki M, Saltiki K, Mantzou E, Anastasiou E, Huhtaniemi I. Eur J Endocrinol. 2006 Jun;154(6):875-81.

HGH as an Adrenal Stimulator:
(note: proposed that peptides should produce growth hormone):
The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism, by Isidori AM, Kaltsas GA, Perry L, Burrin JM, Besser GM, Monson JP. Clin Endocrinol (Oxf). 2003 May;58(5):601-11.

HCG as a Growth Hormone Stimulator and Pituitary Stimulator:
Effect of human chorionic gonadotropin on growth velocity and biological growth parameters in adolescents with thalassaemia major, by Bozzola M, Argente J, Cisternino M, Moretta A, Valtorta A, Biscaldi I, Donnadieu M, Evain-Brion D, Severi F. Eur J Pediatr. 1989 Jan;148(4):300-3.

HCG as a Hypothalamus Stimulator:
It All Began With Dr. Simeons, Dr Mercola, April 13, 2011.

Can the HCG Diet Reset Your Hypothalamus and Metabolism, by By Dr. Zach LaBoube. Inside Out Wellness, June 9, 2015.

HGH as a Thyroid Stimulator:
(note: proposed that peptides also stimulate Thyroid):
Thyroid function during growth hormone therapy, by Jørgensen JO, Møller J, Skakkebaek NE, Weeke J, Christiansen JS. Horm Res. 1992;38 Suppl 1:63-7.

Pregnenolone as a Thyroid Stimulator:
Effect of pregnenolone-16 alpha-carbonitrile on the activity of the rat thyroid gland and anterior pituitary, by Japundzic M, Bastomsky Ch, Japundzic I. Bull Assoc Anat (Nancy). 1975 Jun;59(165):419-26.

Pregnenolone as a Pituitary Stimulator:
Pregnenolone sulfate regulates prolactin production in the rat pituitary, by Kang EJ1, Hong SH1, Lee JE, Kim SC, Yang HS, Yi PI, Lee SM, An BS. J Endocrinol. 2016 Sep;230(3):339-46. doi: 10.1530/JOE-16-0088.

Peptides as a Hypothalamic Stimulator:
Effects of hypothalamic peptides on the aging brain, by Sadow TF, Rubin RT. Psychoneuroendocrinology. 1992 Aug;17(4):293-314.

HGH as an Adrenal, Progesterone and Estrogen Stimulator:
(note: proposed that peptides can serve as this stimulator)
Growth hormone in the management of female infertility, by Navneet Magon, Swati Agrawal Sonia Malik and K. M. Babu. Indian J Endocrinol Metab. 2011 Sep; 15(Suppl3): S246–S247.

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